Tom O’Brien is an expert on gluten sensitivity in the USA.  Undigested proteins from gluten can make it into the brain and cause a range of problems.  Here’s what he has to say on it’s effects


  • “A study has now demonstrated that gluten is independently associated with depression in patients with NCGS.” (READ MORE)
  • “Exposure to gluten specifically induced current feelings of depression.” (READ MORE)
  • “Lifetime depressive symptoms may be present in one third of the CD patients who adhere to gluten free diet. Long-term adherence to the gluten-free diet may reduce the risk of current depressive symptoms.” (READ MORE


  • Emerging scientific literature contains several reports linking gluten sensitivity states with neuropsychiatric manifestations including autism, schizophrenia, and ataxia. (READ MORE)
  • Five biomarkers of gluten sensitivity were found to be significantly elevated in patients with non-affective psychoses (schizophrenia) compared to controls. (READ MORE)

  • Aberrant TG activity is thought to contribute to Alzheimer disease, Parkinson disease, Huntington disease, and supranuclear palsy. (READ MORE)
  • a-Synuclein is a key pathogenic protein that increases in Parkinson’s disease. Elevated transglutaminase levels (the biomarker in the blood for Celiac Disease) is associated with increase a-Synuclein. (READ MORE)
  • Blockade of transglutaminase activity counteracts a-synuclein accumulation in living cells. (READ MORE)

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